Renal Cell Cancer Update
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Robert A Figlin, MD
Acting Cancer Center Director
Arthur and Rosalie Kaplan
Professor of Medical Oncology
Chair, Division of Medical Oncology
and Experimental Therapeutics
City of Hope National Medical
Center/Beckman Research
Institute; Associate Director for Clinical Research
City of Hope
Comprehensive Cancer Center
Duarte, California

 
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Track 1 Overall survival with first-line sunitinib versus interferon for metastatic renal cell carcinoma (mRCC)
Track 2 Prolonging survival in advanced renal cell carcinoma (RCC) with targeted therapy
Track 3 Potential relationship between circulating VEGF levels and response to VEGF tyrosine kinase inhibitor
(TKI) therapy
Track 4 Correlation between hypertension and response to bevacizumab/interferon
Track 5 VEGF rebound and escape angiogenic pathways
Track 6 Antitumor efficacy in RCC with mTOR inhibitors

Track 7 Toxicities with the combination of sunitinib and bevacizumab
Track 8 Patient adherence to oral anticancer therapies
Track 9 Safety and efficacy of sorafenib in elderly patients
Track 10 Front-line interleukin-2 (IL-2) for healthy, younger patients with mRCC
Track 11 Potential risks of therapy with IL-2
Track 12 Bevacizumab monotherapy in previously untreated mRCC
Track 13 Front-line bevacizumab/interferon versus sunitinib in clinical practice
Track 14 Temsirolimus as first-line therapy for poor-risk mRCC
Track 15 Second-line mTOR inhibitors after anti-angiogenic therapy
Track 16 Randomized, Phase II BeST trial of bevacizumab, sorafenib and temsirolimus in advanced RCC
Track 17 Risks associated with combining mTOR inhibitors and TKIs
Track 18 Intergroup adjuvant trial comparing sorafenib to sunitinib to placebo
Track 19 Tolerance of side effects of sunitinib and sorafenib in trials of adjuvant therapy
Track 20 Clinical trials with novel agents in the adjuvant setting
Track 21 Managing toxicities associated with targeted therapies
Track 22 TKI-associated nonulcerative stomatitis
     

Gary R Hudes, MD
Director, Genitourinary
Malignancies Program
Department of Medical Oncology
Fox Chase Cancer Center
Philadelphia, Pennsylvania

 
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Track 1 Phase III trial of everolimus versus placebo in patients with mRCC progressing on sunitinib and/or sorafenib
Track 2 Everolimus and improved disease stabilization
Track 3 Similarities in efficacy and toxicity of everolimus and temsirolimus
Track 4 AVOREN trial: Interferon alpha-2a with or without bevacizumab as first-line therapy for mRCC
Track 5 Clinical trials of bevacizumab combined with interferon

Track 6 Efficacy of front-line sunitinib versus bevacizumab/interferon
Track 7 Etiology of hyperglycemia secondary to mTOR inhibitors
Track 8 Hypercholesterolemia and hyperlipidemia associated with mTOR inhibitors
Track 9 Toxicities in a Phase I trial combining sunitinib and temsirolimus
Track 10 Toxicities observed with the combination of sunitinib and bevacizumab
Track 11 Emerging trials comparing front-line combinations of novel biologics in mRCC
Track 12 Updated efficacy data from a clinical trial comparing sunitinib versus interferon for mRCC
Track 13 ASSURE trial: Sunitinib versus sorafenib versus placebo in patients with high-risk tumors
Track 14 Management of side effects secondary to TKIs
Track 15 Clinical trial evaluating optimal duration of adjuvant sorafenib
Track 16 Impact of bevacizumab on wound healing
Track 17 Defining adverse prognostic factors
Track 18 Completion of clinical trials in uncommon tumors
Track 19 Incidence and treatment of nonclear cell RCC
Track 20 Limitations of RECIST criteria to predict survival benefit with biologic agents
     
Ronald M Bukowski, MD
Emeritus Staff and Consultant
Cleveland Clinic Foundation
Taussig Cancer Center
Professor of Medicine
CCF Lerner College of Medicine
of CWRU
Cleveland, Ohio

 
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Track 1 Everolimus versus placebo after progression on sunitinib and/or sorafenib in mRCC
Track 2 Toxicity and efficacy data with everolimus after sunitinib and/or sorafenib
Track 3 Tolerability and efficacy of the mTOR inhibitors temsirolimus and everolimus
Track 4 Efficacy of sunitinib compared to interferon in mRCC
Track 5 Tolerability of TKIs in elderly patients
Track 6 Updated AVOREN trial efficacy and toxicity data

Track 7 Clinical trial of bevacizumab with or without erlotinib in mRCC
Track 8 Bevacizumab monotherapy in the treatment of mRCC
Track 9 Pitfalls of indirect comparisons of clinical trial data
Track 10 Identifying surrogates to predict benefit from targeted therapies
Track 11 In vitro data demonstrating a relationship between hypoxia-inducible factor (HIF) and tumor sensitivity
to sunitinib
Track 12 Antitumor effect of sunitinib
Track 13 Correlation between HIF levels and rate of tumor regression in patients treated with sunitinib
Track 14 Elevated HIF levels predict poor prognosis
Track 15 Potential nonsynonymous single nucleotide polymorphisms (nsSNPs) associated with sunitinib-associated toxicity
Track 16 Clinical trials combining bevacizumab and TKIs
Track 17 Active clinical trials comparing monotherapy versus combination therapy in mRCC

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